Endocrine Abstracts

Background: An adrenal incidentaloma (AI) is defined as an adrenal lesion that is discovered when a radiological study is performed for indications other than suspected adrenal disease. All patients with an AI should be evaluated for endocrine adrenal functioning and malignancy potential features. A combination of pheochromocytoma and Cushing’s syndrome in same adrenal gland is extremely rare. We report a case of AI with the evidence of both pheochromocytoma and sub-clini...

Introduction: The association of multi-organ autoimmune diseases is described. We report a case of association between Latent autoimmune diabetes in adults (LADA) and systemic scleroderma (SSc), which remains a rarely reported entity in the literature.Observation: 38-year-old female patient, followed for systemic scleroderma with digestive and pulmonary involvements. The patient presented a dysphagia to solids with dyspnea installed in the last 2 months,...

Introduction: Insulin resistance is one of the characteristic abnormalities of type 2 diabetes. Recently it has been recognized that type 1 diabetes may also present with insulin resistance of varying intensity. We report a case of insulin resistance in a patient with type 1 diabetes.Observation: The patient was 23 years old, with a history of type 1 diabetes since the age of 20, with positive antibodies against GAD (glutamate acid decarboxylase), reveal...

Introduction: Type 1 diabetes is accompanied by a high frequency of autoimmune diseases.The aim: of this study is to determine the different epidemiological, clinical, immunological and therapeutic aspects of Type 1 Diabetes in Autoimmune Polyendocrinopathy and to analyze the results obtained.Patients and methods: This is a retrospective study of 44 patients with type 1 diabetes, suffering from Autoimmune Polyendocrinopathy and fol...

Introduction: Compared to normal population, patients with neurofibromatosis are at higher risk for the development of benign and malignant tumors. Pheochromocytomas are relatively rare in neurofibromatosis type 1 (NF1), and malignant ones are even rarer.Aim of the presentation: Our aim was to report a malignant pheochromocytoma with multiple metastases in a patient with NF1.Case report: A male patient aged 23 years old, with lapar...

Introduction: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that arises from the parafollicular C-cells of the thyroid gland with a tendency to regional and distant metastases. It is a rare tumor, making up about 3% of all thyroid malignancies. MTC occurs in both heritable and sporadic forms, early diagnosis is important as it can improve treatment outcomes. We report a case of metastatic medullary thyroid cancer with both diagnostic and therapeutic challenges. <...

Hypoglycemia in non-diabetic patients is a rare event, and autoimmune hypoglycemia with the presence of positive anti-insulin antibodies is even rarer.We report the case of a 15 years old non diabetic female patient, she was referred to our hospital for recurrent hypoglycemia for 2 weeks before admission to hospital, these are severe hypoglycemia with impaired consciousness. The first step was to eliminate the general causes and factitious hypoglycemia. ...

Introduction: Pituitary adenomas are a rare condition in children and young people. The prolactinoma represents the most frequent of them. We report a case of an atypically evolution of aggressive macroprolactinoma in young patient.Case: It’s about a boy of 14 years old with previous history of headache from 5 years without visual disturbance. He was admitted for intracranial hypertension syndrome. In clinical examination no dysmorphic syndrome, a g...

Introduction: Clinically non-secreting pituitary adenomas are rare in children We report a case of a silent somatotropic adenoma revealed by anatomopathology.Case: A 13 year-old patient with no prior history of sudden onset intracranial hypertension syndrome. Clinical examination showed no dysmorphic Syndrome, no galactorrhea, no delay or statutory advance, Tanner P1S3. The MRI reveals a heterogeneous tumor process intra and suprasellar of 30 mm *15 mm o...

Introduction: Pituitary adenomas are rare in infants and adolescents. Prolactinomas account for 50% of these pituitary adenomas. In adolescent girls, it is usually a microprolactinoma revealed by puberty delay or amenorrhea. We report a rare case of a macroprolactinoma in an adolescent girl revealed by visual impairment.Case presentation: A 15-year-old adolescent girl presented with loss of vision over a long period of time. Magnetic resonance imaging re...